Chemical engineering is a branch of engineering that uses principles of chemistry, physics, mathematics, and economics to efficiently use, produce, transform, and transport chemicals, materials, and energy. A chemical engineer designs large-scale processes that convert chemicals, raw materials, living cells, microorganisms, and energy into useful forms and products. Chemical engineers are involved in many aspects of plant design and operation, including safety and hazard assessments, process design and analysis, control engineering, chemical reaction engineering, construction specification, and operating instructions. Advancements in computer science found applications designing and managing plants, simplifying calculations and drawings that previously had to be done manually. The completion of the Human Genome Project is also seen as a major development, not only advancing chemical engineering but genetic engineering and genomics as well. Chemical engineering principles were used to produce DNA sequences in large quantities.